IBMC
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web del Instituto de Biología Molecular y Celular
Dr. Jesus Miguel Sanz Morales

Unit: Molecular and Cellular Design
Subunit: Molecular Recognizement and Protein Engineering
Group: Protein Biotechnology
Category: Investigator
Phone: + 34 966 65 84 60
Email: jmsanz@umh.es
LinkedIn: jesus-miguel-sanz
Personal web page: http://ibmc.umh.es/jmsanz/
Degree: Chemistry
Ph.D program:
Universidad Complutense de Madrid (Supervisors: Dr. José Luis García López and Pedro García González), 1991.
Postdoctoral Positions:
1.- Medical Research Council contract. Cambridge Centre for Protein Engineering. University of Cambridge (United Kingdom). Folding studies on barnase (Prof. Alan R.Fersht) 1992.
2.- EMBO long-term fellowship. Cambridge Centre for Protein Engineering. University of Cambridge (United Kingdom). Folding studies on barnase (Prof. Alan R.Fersht) 1992-1994.
3.- Research fellowship from the Fundación Gregorio Marañón funded by Boehringer Ingelheim. Centro de Investigaciones Biológicas (CSIC, Madrid). Structure of fibroblast growth factor (Dr. Guillermo Giménez) 1994.
4.- Contrato de Reincorporación de Doctores y Tecnólogos (MEC)Centro de Investigaciones Biológicas (CSIC, Madrid). Structure of fibroblast growth factor (Dr. Guillermo Giménez) 1994-1997.
Previous positions:
1.- Fellowship for Research Initiation (CSIC). Centro de Investigaciones Biológicas (CSIC, Madrid) 1988-1989.
2.- Predoctoral fellowship from Ministerio de Educación y Ciencia (Spain).Centro de Investigaciones Biológicas (CSIC, Madrid) 1990-1992.
Current Position: Professor of Biochemistry and Molecular Biology (Since 1999).
Research Fields:
Nanobiotechnology
Protein immobilization on bioplastics
Design of novel antimicrobials

Representative Publications:

  • Hernández-Rocamora, V.M., et al. Multivalent choline dendrimers as potent inhibitors of pneumococcal cell wall hydrolysis. Angew. Chem. Int. Ed. 48, 948-951 (2009)
  • Maestro, B., et al. Recognition of peptidoglycan and beta-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae. FEBS Lett. 585, 357-363 (2011)
  • Maestro et al. A New Family of Intrinsically Disordered Proteins: Structural Characterization of the Major Phasin PhaF from Pseudomonas putida KT2440. PLoS ONE. 8 - 2, pp. e56904 (2013)
  • Silva-Martin, N; et al. Crystal structures of CbpF complexed with atropine and ipratropium reveal clues for the design of novel antimicrobials against Streptococcus pneumoniae. Biochimica et Biophysica Acta (BBA) - General Subjects. 1840, pp. 129 - 135. (2014).
  • Bello-Gil, D., et al. Specific and Reversible Immobilization of Proteins Tagged to the Affinity Polypeptide C-LytA on Functionalized Graphite Electrodes. PLoS ONE 9, e87995 (2014)


Patents:
  • Patent 1.- Inventors: Sánchez-Puelles, J.M., Sanz, J.M., García, J.L. and García, E. Application: 9100732. Publication: ES 2 032 717. Proprietor: Consejo Superior de Investigaciones Científicas. Contracting States: Spain. Date of publication: 16/02/1993
  • Patent 2.- Inventors: Maestro, B., Arévalo, M., Hernández, V.M., Cebolla, A. and Sanz, J.M. Application: P200700281. Proprietor: Universidad Miguel Hernández. Contracting States:Spain. Priority date: 29-1-2007. Licensed to Biomedal S.L. (Sevilla). Marketed as http://tinyurl.com/lytagsystem
  • Patent 3.- Inventors: Sanz, J.M , Maestro, B., Arévalo, M., Velasco, I. and Cebolla, A. Application: P200702504. Publication: ES 2 319 844 Contracting States: Spain. International application: WO 2009/034203 A1. Proprietors: Universidad Miguel Hernández and Biomedal S.L. Licensed to Biomedal S.L. (Sevilla). Marketed as http://tinyurl.com/lytagsystem2
Company agreements:
  • Asesoramiento para la purificación y caracterización del factor humano de crecimiento de osteocitos BMP-7 y otras proteínas de la familia de TGFbeta a partir de plantas de Nicotiana sp. Contrato de asesoramiento con Agrenvec S.L (Madrid) (2008)
  • DECOENZYM – Investigación de la degradación de colorantes residuales mediante la aplicación de la tecnología enzimática. Contrato de investigación con AITEX - Instituto Tecnológico Textil (Alcoy, Alicante) (2014)