IBMC
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web del Instituto de Biología Molecular y Celular
Dr. José Luis Neira Faleiro

Unit: Molecular and Cellular Design
Subunit: Molecular Recognizement and Protein Engineering
Group: Structure of biomolecules
Category: Investigator
Phone: + 34 966 65 84 59
Email: jlneira@umh.es
Degree: Chemistry
Ph.D program:
PhD degree in Chemistry with Honors and Prize to the best Thesis in the whole Universidad Complutense de Madrid (1993).
Postdoctoral Positions:
Long-term EMBO fellow, 3 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/03/1994.
Human Capital and Mobility fellow (24 months). Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/06/1994.
Contract for a non-clinical research scientist of MRC, UK, 7 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/06/1996.
Postdoctoral fellow MEC (PFPI), 24 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/01/1997.
Consulting works for the company Cambridge Combinatorial Ltd, 4 months Cambridge Combinatorial, The Merrifield centre, Rosemary Lane, Cambridge, UK. 1/11/1998.
Contract for a non-clinical research scientist of MRC, UK, 2 months Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/01/1999.
Previous positions:
Fellow of Introduction to Research (2 years), CSIC Instituto de Estructura de la Materia, CSIC. 1/01/1988.
Ph. D. fellow, MEC (4 years). Instituto de Estructura de la Materia, CSIC. 1/01/1990.
Short-term EMBO fellow (6 weeks). Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/07/1991.
Long-term EMBO fellow, 3 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/03/1994.
Human Capital and Mobility fellow (24 months). Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/06/1994.
Contract for a non-clinical research scientist of MRC, UK, 7 months Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/06/1996.
Postdoctoral fellow MEC (PFPI), 24 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/01/1997.
Consulting works for the company Cambridge Combinatorial Ltd, 4 months Cambridge Combinatorial, The Merrifield centre, Rosemary Lane, Cambridge, UK. 1/11/1998.
Contract for a non-clinical research scientist of MRC, UK, 2 months Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/01/1999.
Contract of MEC, 4 months. Instituto de Estructura de la Materia, CSIC. 1/03/1999.
Assistant professor (interim). University Miguel Hernández, Elche (Alicante) Spain. 1/7/1999-21/3/2002.
Current Position: Professor of Physical Chemistry (2010).
Research Fields:
Structure of biomolecules, NMR, fluorescence, Binding, biophysics, protein-drug interactions, peptides, circular dichroism.
Representative Publications:

  • INTERACTIONS BETWEEN SMALL MOLECULES AND THE CAPSID PROTEIN OF HIV-1: DESIGNING INHIBITORS OF CAPSID ASSEMBLY. NEIRA, J.L. (2009) FEBS J 276, 6110-6117.
  • THE BROZE AGE OF SCIENCE IN SPAIN. NEIRA, J.L. AND CARBAJO, R. J. (2010) EMBO REPORTS 11, 12-13.
  • THE REGULATORY FACTOR SIPA IS A HIGHLY STABLE BETA-II CLASS PROTEIN WITH A SH3 FOLD. LÓPEZ-REDONDO, M.L., CONTRERAS, A, MARINA, A. AND NEIRA, J.L. (2010). FEBS LETTERS 584, 989-994.
  • THE BASIC HELIX-LOOP-HELIX REGION OF HUMAN NEUROGENIN 1 IS A MONOMERIC NATIVELY UNFOLDED PROTEIN WHICH FORMS A “FUZZY” COMPLEX UPON DNA BINDING. AGUADO-LLERA, D., GOORMAGHTIGH, E., DE GEEST, N., QUAN, X.-J., PRIETO, A., HASSAN, B., GOMEZ, J., NEIRA, J.L. (2010) BIOCHEMISTRY 49, 1577-1589.
  • FOLDING AND UNFOLDING OF PROTEINS INVOLVED IN PANCREATIC CANCER: A LAYMAN GUIDE. BRAVO, J AND NEIRA, J.L. (2010) THE SCIENTIFIC WORLD JOURNAL 10, 1612-1633