IBMC
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web del Instituto de Biología Molecular y Celular
Dr. Francisco Javier Gomez Perez

Unit: Molecular and Cellular Design
Subunit: Molecular Recognizement and Protein Engineering
Group: Biothermodynamics of molecular recognition processes
Category: Investigator
Phone: + 34 966 65 84 67
Email: jgomez@umh.es
Degree: Chemistry
Ph.D program:
PhD degree with Honors and Prize to the best Thesis at the Chemistry program, Universidad Nacional de Educación a Distancia (U.N.E.D.) – Consejo Superior de Investigaciones Científicas (C.S.I.C.). Directors: Profs. José Laynez Vallejo and Rosa Mª Claramunt Vallespí, 1992.
Postdoctoral Positions:
The Biocalorimetry Center. Departmet of Biology. The Johns Hopkins University. Structural thermodynamical description of molecular recognition processes (Prof. Ernesto Freire).
Previous positions:
1.- Predoctoral fellowship from Universidad Nacional de Educación a Distancia (U.N.E.D.). Department of Chemistry. 1989-1992.
2.- Postdoctoral Fellow. The Biocalorimetry Center. Departmet of Biology. The Johns Hopkins University. 1993–1995.
3.- Research Associate Scientist. The Biocalorimetry Center. Departmet of Biology. The Johns Hopkins University. 1995–1997
Current Position: Assitant Professor of Physical Chemistry (since 1997).
Research Fields:
1.- Structural thermodynamical description of molecular recognition processes.
2.- Therdynamics of protein folding.
3.- Development of strategies to prevent protein aggregation
Representative Publications:

  • The N-terminal domain of the enzyme I is a monomeric well-folded protein with a low conformational stability and residual structure in the unfolded state. 2010. M. Romero-Beviar; S. Martínez-Rodríguez.; J. Prieto.; E. Goormaghtigh; U. Ariz; M.L. Martínez-Chantar; J. Gómez and J.L. Neira. PEDS: Protein Engineering, Design and Selection 49, 1577–1589.
  • Thermodynamic analysis of the conformational stability of the Streptomyces coelicolor histidine-phosphocarrier protein: characterization of cold denaturation and urea-protein. J.L. Neira and J. Gómez. 2004. Eur. J. Biochem. 271, 2165–2181.
  • Enzyme kinetics determined using calorimetry: A General Assay for Enzymatic Activity? M.J. Todd & J. Gómez. 2001. Analytical Biochemistry 296, 187–197.
  • Thermodynamic Mapping of the Inhibitor Binding Site of the Aspartic Protease Endothiapepsin. 1995. J. Gómez & E. Freire. Journal of Molecular Biology 252, 337–350.
  • The Heat Capacity of Proteins. 1995. J. Gómez; V.J. Hilser; D. Xie and E. Freire. Proteins: Structure, Function and Genetics 22, 404–412.