IBMC
ibmc01 ibmc02 ibmc03 ibmc04 ibmc05 ibmc06 ibmc07 ibmc08 ibmc09 ibmc10 ibmc11 ibmc12
jQuery Image Slider by WOWSlider.com v2.0
web del Instituto de Biología Molecular y Celular

THE IBMC SCIENTIFIC PROGRAM


The IBMC has established a unique research and training program, which exploits multidisciplinarity, making the most of the complementarities of the groups and using synergies as a strategy for attaining excellence and increasing competitiveness and productivity. To accomplish this aim, in the last two years, research has been organized into two complementary areas of research, namely, (i) molecular and cell design and (ii) molecular diagnosis and therapy. These research lines, in turn, are organized into sub-areas, which rationally combine the groups’ abilities and skills in the supplementary fields that contribute to the development of bioactive molecules, reducing scientific dispersion by grouping activities in order to carry out unique and ambitious research projects. Consequently, in the next five-year period, the IBMC aspires to become a center of reference in the discovery of pharmacological and biotechnological tools, with a clear translational and transfer potential. The intense and sustain work in this line is the central objective for the next five year period, and to so agreements with PROs will be pursued which will permit reinforcing deficient areas or those that require an impetus for their consolidation, and thereby generating a unique and unprecedented project on a national and international level.

In scientific terms, the targets of these research areas of the IBMC are developed as follows:

B. Diagnosis and Molecular Therapy

Research within the line of Molecular and Cellular Design aims at advancing knowledge of relationships between structure and function in proteins, in order to be able to modify them rationally and specifically. The underlying goal is the transformation of the activity of these proteins with bio and chemo-technological purposes, or the use of the information to design targeted ligands to modulate the receptor activity acting as sensors.

The line of investigation has 9 researchers (7 consolidated and 2 more in the process of consolidation) organized in five research groups, although not in all of them there is a sufficient critical mass to achieve successfully the scientific objectives pursued. The different scientific backgrounds of the researchers who develop this research line allows a reasonably and pluridisciplinary (though improved) approach to analyze problems, offering an opportunity for the development of common interests and benefiting from synergies that naturally appear in this context. This multidisciplinary approach of issues enables a broad focusing on scientific topics, ranging from a perspective of basic science to investigations with clear translational vocation.

Both the composition of the different research groups that make up this line of research as its multidisciplinarity and flexibility to raise specific scientific goals fosters a high competitiveness, both in the uptake of competitive sources and scientific production, in the training of research personnel and in the technological transfer of research results. In this sense, , strong links with research groups both national as international have been notably established, which have materialized, for example, in leadership or participation in projects coordinated with other institutions both within the different National Plans of Research, including projects CONSOLIDER, and funded by the European Union and recently granted.

Molecular and Cellular Design line is organized into two sub-lines, each comprising several research groups with common research interests. The first in centered around Molecular Recognition and Protein Biophysics and Engineering, while the second focuses his research on Structure-Function Relationships in Membrane Proteins.

B. Diagnosis and Molecular Therapy

The Diagnosis and Molecular Therapy line seeks the identification and validation of molecular markers in human and animal pathologies of high prevalence, as well as the development of diagnostic methods and therapeutic or preventive strategies. This line consists of a multidisciplinary team of researchers covering from molecular aspects to the semi-industrial production of biological actives. Such multidisciplinarity is sustained by the contribution of 12 researchers (10 consolidated and 2 more in the process of consolidation) organized in six research groups, which provides a balanced composition and favors a high competitiveness both in scientific contributions, as in the abstraction of resources, training of research personnel and generating transferable and exploitable technologies.

Milestones achieved in this line of research have had and have a high scientific impact, as shown by scientific publications in magazines of recognized international prestige, as well as the generation of unique technologies that are protected by patents extended worldwide and have been licensed to interested companies. Also, it should be noted as a strong point of this line the high level of national and international collaborations with public bodies and private research, contributing to increase the impact of activities and its internationalization. In addition, the interrelationship of the sub-lines that make up this line of research has fostered identifying synergies and common interests between groups that have driven collaborations that accelerate the achievement of results and technologies.

Clearly, the activities of this line have a high potential for clinical translation materialized in close collaboration with the General Hospital and the University of Elche, as well as biotechnology transfer and exploitation resulting in continuous and consolidated collaborations with biotech, food and pharmaceutical companies.