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web del Instituto de Biología Molecular y Celular
Dr. José Manuel González Ros

Unit: Molecular and Cellular Design
Subunit: Structure-function relationships in membrane proteins
Group: Structure-function of potassium ion channels
Category: Investigator
Phone: + 34 966 65 87 57
Degree: Biological Sciences, 1974
Ph.D program: PhD in Biochemistry, 1977. Universidad Complutense de Madrid (Advisor: Prof. Antonio Ribera Blancafort)
Previous positions:
1997, Catedrático. Univ. Miguel Hernández
1987-97, Catedrático. Univ. Alicante
1984-87, Catedrático. Univ. Islas Baleares
1981-84, Assistant Professor. Medical College of Virginia, USA
1980-81, Research Associate. Medical College of Virginia, USA
1978-80, Research Fellow, Medical College of Virginia, USA
1977-78, Prof. Adjunto Interino. Univ. Alcalá de Henares
1976-77, Prof. Encargado. Univ. Complutense de Madrid
1974-76, Prof. Ayudante. Univ. Complutense de Madrid
Director, Institute of Molecular and Cellular Biology, 1998-2012.
Current Position: Catedrático de Universidad (Bioquímica y Biología Molecular).
Research Fields:
Structure/Function relationships in membrane proteins: Neuroreceptors and ion channels. Lipid-Protein and Protein-Protein interactions in biological membranes. Potential applications to drug discovery.
Representative Publications:

  • A. M. Fernández, J. A. Poveda, J. A. Encinar, A. Morales and J. M. Gonzalez-Ros: “Estructural and functional modulation of ion channels by specific lipids: from model systems to cell membranes”, in Protein-Lipid interactions: New approaches and emerging concepts (C. R. Mateo, J. Gómez, J.Villalaín and J. M. González Ros, Eds.), pp. 203-231, Springer Series in Biophysics 9. Springer, Heidelberg (2006)
  • M. L. Molina, F. N. Barrera, A. M. Fernandez, M. L.Renart, J. A. Poveda, J. A. Encinar, G. Riquelme and J. M. Gonzalez-Ros: “Clustering and coupled gating modulate the activity in KcsA, a potassium channel model”. J. Biol. Chem. 281, 18837-18848 (2006)
  • M. L. Renart, F. N. Barrera, M. L. Molina, J.A. Encinar, J. A. Poveda, A. M. Fernández, G. Riquelme, J. Gómez and J. M. Gonzalez-Ros: “Effects of conducting and blocking ions on the structure and stability of the potassium channel KcsA”. J. Biol. Chem. 281, 29905-29915 (2006)
  • F. Barrera, M.L. Renart, J.A. Poveda, B. de Kruijff, A.J. Killian and J.M. Gonzalez-Ros: “Protein self-assembly and lipid binding in the folding of the potassium channel KcsA”. Biochemistry 47, 3123-2133 (2008)
  • I. Triano, F.N. Barrera, M.L. Renart, M.L. Molina, G. Fernandez-Ballester, J.A. Poveda, A.M. Fernandez, J.A. Encinar, A.V. Ferrer-Montiel, D. Otzen and J.M. Gonzalez-Ros: “Occupancy of non-annular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein” Biochemistry, 49(25): 5397-5404 (2010)

Patents and Available Technologies: