IBMC
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web del Instituto de Biología Molecular y Celular

Group name: PROTEIN STRUCTURE AND THERMODYNAMICS OF MOLECULAR RECOGNITION


Our group is involved in the study, by using calorimetric and spectroscopic techniques, of macromolecular interactions. To that end, the group has the expertise in DSC, ITC, fluorescence and circular dichroism. Furthermore, the group has the knowledge to solve structures by using state-of-the-art techniques. Some, but note exclusively, of the biomolecules currently under study in the group are: (i) those involved in the phosphorylation tranfer in micro-organisms; and (ii) those implicated in the aseembly of the capsid of HIV.

RESEARCH HIGHLIGHTS

EMBO Rep. 2010; 11: 12-13. The broze age of science in Spain. Neira JL, Carbajo RJ.

FEBS Lett. 2010; 584: 989-994. The regulatory factor SIPA is a highly stable Beta-II class protein with a sh3 fold. López-Redondo ML, Contreras A, Marina A, Neira JL

Biomacromolecules 2011: 12: 1015-1023. Effect of chitosan degradation on its interaction with β-lactoglobulin. Souza, H.; Gonçalves, M. and Gómez, J.


STAFF

Javier Gómez-Pérez

José Luis Neira

POSTDOCOTORAL FELLOWS

Rocío Esquembre Tomé

PH.D STUDENTS

Felipe Hornos Adán

PUBLICATIONS (ARTICLES)

  1. FEBS J 2009; 276: 6110-6117. Interactions between small molecules and the capsid protein of hiv-1: designing inhibitors of capsid assembly. Neira JL (2009)
  2. Biomacromolecules 2011: 12: 1015-1023. Effect of chitosan degradation on its interaction with β-lactoglobulin. Souza, H.; Gonçalves, M. and Gómez, J.
  3. EMBO Rep. 2010; 11: 12-13. The broze age of science in Spain. Neira JL, Carbajo RJFEBS Lett. 2010; 584: 989-994. The regulatory factor SIPA is a highly stable Beta-II class protein with a sh3 fold. López-Redondo ML, Contreras A, Marina A, Neira JL
  4. Journal of Biomaterials Science: Polymer Edition 2012; 1 – 16. Synthesis and Characterization of a Novel Thermoresponsive Copolymer Series and their Application in Cell and Cell Sheet Regeneration. Nash, M.E; Carroll W.M.; Velasco D.; Gomez, J.; Gorelov A.V.; Elezov D.; Gallardo A.; Rochev Y.A. and Elvira C.
  5. Biochemistry 2010; 49: 1577-1589. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon dna binding. Aguado-Llera D, Goormaghtigh E, De Geest N, Quan, X-J, Prieto, A, Hassan, B, Gómez, J, Neira JL
  6. Biochemistry 2012; 51: 3891–3900 Contribution of Ion Binding Affinity to Ion Selectivity and Permeation in KcsA, a Model Potassium Channel. Renart M.L., Montoya E.; Fernández A.M.; Molina M.L.; Poveda J.A.; Encinar J.A.; Ayala J.L.; Ferrer-Montiel A.V.; Gómez J.; Morales A., and González Ros J.M.
  7. Sci. World 2010; 10: 1612-1633 Folding and unfolding of proteins involved in pancreatic cancer: a layman guide. Bravo H Neira JL
  8. Journal of Biomaterials Science: Polymer Edition 2012; 1 – 16. Synthesis and Characterization of a Novel Thermoresponsive Copolymer Series and their Application in Cell and Cell Sheet Regeneration. Nash, M.E; Carroll W.M.; Velasco D.; Gomez, J.; Gorelov A.V.; Elezov D.; Gallardo A.; Rochev Y.A. and Elvira C.