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web del Instituto de Biología Molecular y Celular

Group name: ESTRATEGIAS ANTIVIRALES EN ACUICULTURA


The group of Virology at the IBMC was established fourteen years ago. The group members have proven expertise over 20 years in the field of viral diseases of fish in aquaculture. The group's interest is focused on the study of viruses, fish immune response related to virus infections and antiviral strategies for disease prevention and treatment:

  • Study of the early steps of rhabdovirus infections.
  • Design of new antivirals using combinatorial chemistry or molecules related to the innate immune response such as AMPs (antimicrobial peptides).
  • Development of environmentally friendly DNA vaccines. Characterization of the immune response induced by DNA vaccines using genomic and proteomic approaches (microarrays) to determine the molecular bases of protection conferred by these vaccines.

RESEARCH HIGHLIGHTS

Vet Microbiol. 2013 Oct 25;166(3-4):412-8. doi: 10.1016/j.vetmic.2013.06.022. Epub 2013 Jul 9. Antiviral activity produced by an IPNV-carrier EPC cell culture confers resistance to VHSV infection. Jurado MT, García-Valtanen P, Estepa A, Perez L.

Este trabajo muestra la producción de actividad antiviral en cultivos de células de carpa persistentemente infectadas por el birnavirus IPNV, y cómo sobrenandantes de estos cultivos inducen protección de las células frente a la infección por otros dos virus: VHSV y SVCV. Esta protección estaría mediada por un factor soluble tipo interferón.

Autophagy. 2014 Sep;10(9):1666-80. doi: 10.4161/auto.29557. Epub 2014 Jul 16. Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules/. García-Valtanen P1, Ortega-Villaizán Mª del M, Martínez-López A, Medina-Gali R, Pérez L, Mackenzie S, Figueras A, Coll JM, Estepa A.

La autofagia es una estrategia de defensa de las células frente a la infección viral; una especie de muerte celular programada para evitar la infección. En este artículo se muestra la inducción de autofagia por los virus VHSV y SVCV en una línea celular de pez cebra. Es el primer trabajo en describir este fenómeno en células de pez.





STAFF

Luis Pérez García-Estañ

POSTDOCTORAL FELLOWS

Alberto Falcó Gracia

PH.D STUDENTS

Regla María Medina Gali

Melissa Belló Pérez

TECHNICIANS

Beatriz Bonmatí Botella

PUBLICATIONS (ARTICLES)

  1. Antiviral Res. 2008 Dec;80(3):332-8. doi: 10.1016/j.antiviral.2008.07.007. Epub 2008 Aug 20. Inhibitory effect of mycophenolic acid on the replication of infectious pancreatic necrosis virus and viral hemorrhagic septicemia virus. Marroquí L1, Estepa A, Perez L.
  2. J Virol. 2010 Jul;84(14):7140-50. doi: 10.1128/JVI.00023-10. Epub 2010 May 12. Pepscan mapping of viral hemorrhagic septicemia virus glycoprotein G major lineal determinants implicated in triggering host cell antiviral responses mediated by type I interferon. Chico V1, Martinez-Lopez A, Ortega-Villaizan M, Falco A, Perez L, Coll JM, Estepa A.
  3. PLoS One. 2013 Oct 9;8(10):e77426. doi: 10.1371/journal.pone.0077426. eCollection 2013. Increasing versatility of the DNA vaccines through modification of the subcellular location of plasmid-encoded antigen expression in the in vivo transfected cells. Martinez-Lopez A1, García-Valtanen P, Ortega-Villaizan Mdel M, Chico V, Medina-Gali RM, Perez L, Coll J, Estepa A.
  4. Vet Microbiol. 2013 Oct 25;166(3-4):412-8. doi: 10.1016/j.vetmic.2013.06.022. Epub 2013 Jul 9. Antiviral activity produced by an IPNV-carrier EPC cell culture confers resistance to VHSV infection. Jurado MT1, García-Valtanen P, Estepa A, Perez L.
  5. Antiviral Res. 2014 Jan;101:136-47. doi: 10.1016/j.antiviral.2013.11.009. Epub 2013 Nov 25. In addition to its antiviral and immunomodulatory properties, the zebrafish β-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. García-Valtanen P1, Martinez-Lopez A1, Ortega-Villaizan M1, Perez L1, Coll JM2, Estepa A3.
  6. Autophagy. 2014 Sep;10(9):1666-80. doi: 10.4161/auto.29557. Epub 2014 Jul 16. Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. García-Valtanen P1, Ortega-Villaizán Mª del M, Martínez-López A, Medina-Gali R, Pérez L, Mackenzie S, Figueras A, Coll JM, Estepa A.