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web del Instituto de Biología Molecular y Celular
Dr. Asia Fernandez Carvajal

Unit: Molecular diagnosis and therapy
Subunit: Bioactives molecules
Group: Pain signaling: Design of drugs on TRP receptors.
Category: Investigator
Phone: + 34 966 65 84 54
Degree: Biology
Ph.D program: PhD degree with honors and prize to the best Thesis at the Neuroscience program, Alicante University (Director: Prof José Manuel Gonzalez Ros, 1992)
Previous positions:
1.- 1988-1991: Predoctoral Fellowship from M.E.C.: Department of Neurochemistry. Medicine Faculty University of Alicante.
2.- 1992-1995: Postdoctoral Fellowship from European Comunity. Investigation in Neuroreceptors and ionic channels.
3.- 1988-1997: Lecturer in Biochemistry. Department of Neurochemistry. Medicine Faculty. University of Alicante.
4.- 1997-2009: Assistant Profesor of Enzimology and Biochemistry. Department of Biochemistry and molecular. UMH University.
Current Position: Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez.
Research Fields:
- High throughput screening.
- Discovery and development of anti-nociceptive drugs.
- Structure-function studies on ion channels.

Representative Publications:

  • A. Bertaminoa, C. Ostacolo, P. Ambrosino, S. Musella, V. Di Sarno, T. Ciaglia, M.V. Soldovieri, N. Iraci, A. Fernandez-Carvajal, R. A. Ferrer-Montiel, R. Gonzalez Muñiz, E. Novellino, M. Taglialatela, P. Campiglia, I. Gomez-Monterrey. (2016) Tryptamine-based derivatives as Transient Receptor Potential Melastatin type-8 (TRPM8) channel modulators. Journal of Medicinal Chemistry 59(5):2179-91.
  • E. Montoya; M.L. Renart, A.M. Giudici; J.A. Poveda; A.M. Fernandez, A. Morales and J.M. Gonzalez-Ros (2017). Differential binding of monovalent cations to KcsA: Deciphering the mechanisms of potassium channel selectivity. Biochim Biophys Acta. 1859(5):779-788.
  • R. Torre-Martínez, M.A. Bonache, P.J. LLabrés, B. Balsera, A Fernández-Carvajal, G. Fernández-Ballester, A. Ferrer-Montiel, M.J. Pérez de Vega, R. González-Muñiz (2017). Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists. Scientific reports. 7(1):10766-10779.
  • B. Balsera, J. Mulet, S. Sala, F. Sala, R. Torre Martinez, S. González-Rodríguez, A. Plata, L. Naesens, A. Fernández-Carvajal, A. Ferrer-Montiel, M. Criado, M.J. Pérez de Vega and R. González-Muñiz. (2018). Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity. European Journal of Medicinal Chemistry. 143: 157-165.
  • Serafini, M.; Griglio, A.; Aprile, S.; Seiti, F.; Travelli, C.; Pattarino, F.; Grosa, G.; Sorba, G.; Genazzani, A.; Gonzalez-Rodriguez, S; Butron, L.; Devesa, Il; Fernández-Carvajal, A.; Pirali, T. and Ferrer-Montiel, A. (2018). Targeting TRPV1 softly: the discovery of Passerini adducts as a topical treatment for inflammatory skin disorders. Journal of Medicinal Chemistry.

Patents and Available Technologies:
  1. Fernández-Carvajal A, García-Martínez C, Belmonte C, Van Den Nest W, Carreño C., Ferrer-Montiel A. Compounds which can block the responses to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, production method thereof and compositions containing same. ES2195787 B1 (granted on 01/06/2005); WO03/097670; EP1506970 A1; US7183430 B2 (granted on 27/02/2003); AU2003/231331; CA2486342 A1; JP2006/502975 ; MX PA/a/04011502.
  2. Antonio Ferrer Montiel, Asia Fernández Carvajal, Carolina García Martínez, Carlos Belmonte Martínez, Wim van den Nest, Cristina Carreño Serraima. New bis-N-(halophenethyl)-glycyl-glycine derivatives, useful as analgesic medicaments, especially for treating inflammatory or neuropathic pain, or in cosmetic compositions. WO2003097670-A; WO2003097670-A1; ES2195787-A1; AU2003231331-A1; EP1506970-A1; KR2005007406-A; ES2195787-B1; US2005130907-A1; JP2006502975-W; US7183430-B2.
  3. Carlos Belmonte Martínez, Juana Gallar Martinez, Antonio Ferrer Montiel, Asia Fernández Carvajal, Felix Viana de la Iglesia. Título: Composición farmacéutica para el tratamiento del ojo seco. Pharmaceutical composition for the treatment of the dry ice. WO2012/032209 A2 EP2614860A2, EP2614860A4, US20130245231, WO2012032209A3.
Company agreements:
  • BCN Peptides
  • DiverDrugs